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      1. ^Y

        PI 1/4

        PI 1/4 >

        E-mail: dong.gao@@sibcb.ac.cn

          2005\λ2011λ20112016 (The Johns Hopkins University) !о (Memorial Solan Kerttering Cancer Center) о2015!оNYSTEM Fellow20168пооо鳤



          LоIgо (Patients derived organoidsPDO) εЧ020%αgg á

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        (*equal contribution, # corresponding author)
        1.  Blattner M, Liu D, Robinson BD, Huang D, Poliakov A, Gao D, Nataraj S, Deonarine LD, Augello MA, Sailer V, Ponnala L, Ittmann M, Chinnaiyan AM, Sboner A, Chen Y, Rubin MA#, Barbieri CE#. SPOP Mutation Drives Prostate Tumorigenesis In Vivo through Coordinate Regulation of PI3K/mTOR and AR Signaling.Cancer Cell. 2017 Mar 13;31(3):436-451.
        2.  Mu P, Zhang Z, Benelli M, Karthaus WR, Hoover E, Chen CC, Wongvipat J, Ku SY, Gao D, Cao Z, Shah N, Adams EJ, Abida W, Watson PA, Prandi D, Huang CH, de Stanchina E, Lowe SW, Ellis L, Beltran H, Rubin MA, Goodrich DW, Demichelis F, Sawyers CL.SOX2 promotes lineage plasticity and antiandrogen resistance in TP53- and RB1-deficient prostate cancer.Science. 2017 Jan 6;355(6320):84-88.
        3. Yang ZH, Peng YC, Gopalan A, Gao D, Chen Y, Joyner AL. Stromal Hedgehog signaling maintains smooth muscle and hampers micro-invasive prostate cancer. Disease Models & Mechanisms. 2016 : doi: 10.1242/dmm.027417
        4.  Dardenne E*, Beltran H*, Benelli M, Gayvert K, Berger A, Puca L, Cyrta J, Sboner A, Noorzad Z, MacDonald T, Cheung C, Gao D, Chen Y, Eilers M, Mosquera JM, Robinson BD, Elemento O, Rubin MA, Francesca Demichelis F and Rickman DS#. N-Myc induces an EZH2-mediated transcriptional program driving neuroendocrine prostate cancer.  Cancer Cell. 2016 Oct; 30:563-577.
        5. Gao D#, Zhan Y, Di W, Moore AR, Sher JJ, Guan YX, Wang SQ, Zhang ZD, Murphy DA, Sawyers CL, Chi P and Chen Y#. A Tmprss2-CreERT2 knock-in mouse model for cancer genetic studies on prostate and colon. PLoS One 11(8): e0161084.
        6. Drost J*, Karthaus WR*, Gao D, Driehuis E, Sawyers CL, Chen Y and Clevers H#. Organoid culture systems for prostate epithelial tissue and prostate cancer tissue.  Nature Protocols. 2016 Jan; Doi:10.1038/347C358.
        7. Wiesner T, Lee W, Obenauf A, Ran L, Murali R, Zhang Q, Wong E, Hu W, Sasinya S,  Shah R, Scott S, Sboner A, Button J, Landa I, Gao D, Cao Z, Shukla S, , Merghoub T, Schwartz G, Wang L, Ladanyi M, Fagin J, Hollmann T, Busam K, BergerM , Chen Y# and Chi P#. Alternative transcription initiation leads to expression of a novel ALK isoform in cancer. Nature. 2015 Oct;Doi:10.103811.
        8. Ran LL, SirotaI, Cao Z, Murphy D, Chen YD, Shukla S, Xie YY,Gao D, Zhu S, Rossi F, Wongvipat J, Taguchi T, Tap WD, Mellinghoff IK, Besmer P, Antonescu CR, Chen Y# and Chi P#. Combined inhibition of MAP kinase and KIT signaling pathways destabilizes the ETV1 protein and synergistically suppress GIST tumorigenesis. Cancer Discovery. 2015 Jan; DOI: 10.1158/2159-829011.
        9.  Gao D and ChenY#.Organoid Development in Cancer Genome Discovery. Current Opinion in Genetics and Development. 2015 Mar 18; 30:42-48. (Invited Cover Review).
        10. Gao D*, Vela I*, Sboner A*, Iaquinta PJ*, Karthaus WL, Gopalan A, Wanjala JN, Dowling C, Undvall EA, Wongvipat J, Kossai M, Barboza LP, Di W, Cao Z, Zhang QF, Sirota I, Ran Ll, Solomon SB, MacDonald TY, Beltran H, Mosquera J,  Eastham JA, Touijer KA, Scardino PT, Laudone VP, Rathkopf DE, Morris MJ, Danila DC, Slovin SF, Chi P, Clevers H, Carver B, Rubin MA, Scher HI, Sawyers CL#, Chen Y#. Generation of in vitro organoids cultures derived from patients with advanced prostate cancer. Cell, 2014 Sep; 159: 176-187. 
        11.  Karthaus WR, Iaquinta PJ, Drost J, Gracanin A, Wongvipat J, Gao D, Befthel H, Sachs N, Vries RG.J, Cuppen E, Chen Y, Sawyers CL and Clevers H#. Identification of luminal stem cells in the human prostate using a novel epithelial culture system. Cell, 2014 Sep; 159: 163-175.
        12. Zeng Y#, Gao D, Kim JJ, Shiraishi T, Terada N, Kakehi Y, Kong CZ, Getzenberg RH, Kulkarni P#. Prostate-associated gene 4 (PAGE4) protects cells against stress by elevating p21 and suppressing reactive oxygen species production. American Journal of Clinical and Experimental Urology, 2013 Dec; 1(1):39-52.11.
        13. Chen Y, Chi P, Rockowitz S, Iaquinta P.J, Shamu T, Shukla S,Gao D, Sirota I, Carver B.S, Wongvipat J, Scher H.I, Zheng D, Sawyers CL#. ETS factors reprogram the androgen receptor cistrome and prime prostate tumorigenesis in response to PTEN loss.Nature Medicine, 2013 Aug; 19(8):1023-9.11.
        14. Zeng Y#, Wodzenski D, Gao D, Shiraishi T, Terada N, Li Y, Griend D.J.V, Luo J, Kong C, Getzenberg R.H, Kulkarni P#. Stress-response protein RBM3 attenuates the stem-like properties of prostate cancer cells by interfering with CD44 variant splicing.Cancer Research. 2013 Jul; 73(13): 4123-4133.11.
        15. Yang YK, Qu H, Gao D, Zhai ZH, and Chen DY#. ARF-like protein 16(ARL16) inhibits RIG-I by binding with CTD in GTP dependent manner. J. Biol. Chem. 2011, 286: 10568-10580.11
        16. Gao D, Yang YK, Wang RP, Zhou X, Diao FC, Li MD, Zhai ZH, Jiang ZF, and Chen DY#.  REUL is a novel E3 ubiquitin ligase and stimulator of retinoic-acid-inducible gene-I. PLoS One. 2009; 4(6):e5760. 11.
        17.  Gao D*, Wang RP*, Li B, Yang Y, Zhai ZH, and Chen DY#. WDR34 is a novel TAK1-associated suppressor of the IL-1R/TLR3/TLR4-induced NF-kappaB activation pathway. Cell Mol Life Sci. 2009; 6615:2573-84.
        18. Zhang M, Wang RP, Diao FC, Lu F,Gao D, Chen D, Zhai ZH, and Shu HB#. A CXXC ring finger protein is required for DNA damage-induced p53 activation. Science in China Series C: Life Science. 2009; 52(6):528-538.
        19. Zhang M, Tian Y, Wang RP, Gao D, Zhang Y, Diao FC, Chen DY, Zhai ZH, and Shu HB#. Negative feedback regulation of cellular antiviral signaling by RBCK1-mediated degradation of IRF3. Cell Research. 2008 Nov;18(11):1096-104.


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